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General and Systemic Histopathology, C601&C602
     
    Slide 61: Cervical dysplasia
     
     
    This can be a confusing slide if you don't get oriented first.  In the scan at the left you can see both the endocervical and ectocervical regions.  The big dilated cystic, mucin filled glands in the middle are glands of Naboth.  We see these either in the endocervix or at the endocervical-ectocervical junction.  Use them as a landmark to tell where you are. If you see squamous epithelium over these glands, it almost always represents squamous metaplasia.  In this case, there's dysplasia as well.

    See this slide with the virtual microscope.

    This picture pretty well says it all. This condition is viral in nature and some of the viral serotypes are known to be associated with the development of cancer. You will see immature basilar cells carried far up into the epithelial covering. There are many mitoses as well as generalized atypia of the nuclei. These change can look pretty disturbing on a PAP stain. 


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