Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

Papanicolaou stain	H & E stain

• These are some really angry and disturbed cells. (Move cursor)
• Huge nuclei with hyperchromasia and irregular nuclear borders. (Note that the nuclei on the left are twice size of the PMNs.)
• Large, owl-eyed nucleoli (very characteristic of melanomas).
• Varying degrees of melanin production. (Remember, there are amelanotic melanomas.)