General and Systemic Histopathology, C601&C602

    Virtual Slide: 60 Year-old woman complains of cough and shortness of breath.

    Click here to see the blood smear.


    Click the image above for the smear


    This 60 year-old woman complains of fever, shortness of breath and cough. Her cough is productive of a yellow sputum. Physical exam reveals a pale, slight woman with mild cyanosis of the nail beds. Rales are heard in the base of both lung fields.

    WBC  35.9 X 103   RBC   3.81  
           Percent    Abs   HGB   10.7  
    NE    85.5      30.8   HCT    31.7  
    LY      6.2        2.2   MCV   83.2  
    MO     4.3       1.5   MCH   28.1  
    EO     3.7       1.3   MCHC  33.8  
    BA      0.3       0.1   RDW   15.6  
    Bands observed   PLT   375 x 103 Reference values?
    Dohle bodies seen   MPV    9.8  


    Click the blood cell image above too see the blood smear.

    • What about the Dohle bodies?

    • What clinical findings and features of the CBC favor a leukemoid reaction over leukemia?

    • For that matter, what is a leukemoid reaction?

    • Would you expect this person to be PH1 chromosome positive?

    Next patient is a 32 year-old man with an abnormal CBC.

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