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General and Systemic Histopathology, C601&C602
     
    Slide 121: Chronic Myositis
     
     
    Obviously there are several pieces of tissue on this slide.  Look in the strip of muscle.  You are looking for inflammatory cells in between the individual muscle cells as well as disruption of the actin and myosin within the cells.

    See this slide with the virtual microscope.

    You will see many "ratty" looking and fragmented bundles of muscle cells, as well as disrupted actin and myosin within a few of the individual myocytes. There should be no trouble finding the chronic inflammatory infiltrate located between the muscle cells. On low power you should be able to appreciate the great variation in muscle cell diameter. What types of conditions would bring about this change? What serum enzymes would you expect to be elevated in a patient with such a condition?


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