General and Systemic Histopathology, C601&C602
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Again, I think you
can appreciate the inflammatory infiltrate just by noting the focal
and diffuse blue staining of the interstitial tissue. However, the
most important finding here is the microscopic observation of the epithelial
crescents within Bowman's space. See this slide with the virtual microscope. |
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The hallmark of this disastrous condition is the proliferation of the parietal epithelium of Bowman's capsule. The proliferating cells grow into the shape of a "crescent" and may largely replace the space. The crescent is ONLY an indicator of the profound damage to the basement membrane. I doubt that the crescent itself contributes much to the progression of the disease. You should find evidence of marked glomerulonephritis in virtually all glomeruli. |