General and Systemic Histopathology, C601&C602
    Slide 118: Lymph Node with Metastatic Malignant Melanoma
    Although fragmented, you can see the area of involvement in this lymph node. 

    See this slide with the virtual microscope.

    Again the picture pretty well says it all here. You will see a node partially replaced with groups of cells that clearly don't belong there. Many contain abundant dark brown pigment. In general I advise that you look at the subcapsular sinuses and pericortical sinuses for the first evidence of metastatic involvement. Of course, in this case, it is no problem to see the altered histology and the process is considerably advanced. 

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