Hematopoiesis, the process of blood
formation, in adults occurs in bone marrow, under normal
circumstances (Figs. 13-2 and 13-3).
-
 Examine
the marrow cavity of the long bones decalcified and sectioned on
slide 34 and
slide 104.
- Identify adipocytes and estimate
whether this is “red marrow” or “yellow marrow.”
- Note the overall organization of
marrow and identity sinusoids bounded by endothelial cells and
containing circulating blood.
- Identify hemopoietic cords in
the stroma.
- Cells in mitosis should be
visible here.
- Identify the stromal fibroblasts
and large macrophages.
What is the structural
relationship among the endosteum, stroma, hemopoietic cords,
endothelial cells, and sinusoids in marrow?
Clinical note: Since
hematopoietic populations undergo continuous rapid cell renewal,
they are easily damaged by chemo-therapeutic drugs and ionizing
radiation. Want to see how a bone marrow sample is obtained?
Examine slide 153, a section from a
needle biopsy of normal bone marrow which retains much of the normal
organization of the marrow in bone. Identify the cellular
constituents
- Adipocytes,
- Blood sinusoids,
- Hemopoietic cords,
- Megakaryocytes and
- Stromal cells
|
 |
Sketch a region of bone marrow from
slide 153, showing sinusoids, fat cells, stroma, hemopoietic cords,
and if possible megakaryocytes.
Bone marrow
smear. |
