Illness Phase

• Early, acute
• Middle, Chronic
• Final, crisis

• Emergence of AIDS Defining Opportunistic Infections and Neoplasms.
• Long lasting fever (>1 month)
• Fatigue
• Weight loss
• Diarrhea
• Neurological manifestations

The crisis phase is characterized by:

• Breakdown of host defense.
• Dramatic increase in plasma virus load.
• Overt clinical disease.
• CD4+ cell count <200/ul