| Symptoms
& History
Physical
Findings
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& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation
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Associated Neoplasms, Continued
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Kaposi sarcoma in AIDS
patients
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The malignant mesenchymal cells
are induced to grow by growth factors and cytokines released by tumor cells
themselves and HIV infected T-cells.
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KSHV infected B-cells also contribute
to proliferation of the malignant mesenchymal cells.
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Tumor spreads widely; skin,
GI, lymph nodes and lung.
Non-Hodgkin lymphomas in
AIDS patients.
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Observed in 6% of AIDS patients
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Incidence is 120 times that
of general population.
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Development is linked to sustained
polyclonal activation of B-cell population. Prolonged stimulation is followed
by somatic mutations leading to neoplastic transformation.
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