| Symptoms
& History
Physical
Findings
Stop
& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation
|
|
|
Central Nervous System Involvement
in AIDS
|
Macrophages and microglia
are the predominate cells of the CNS infected by HIV.
-
HIV probably arrives in the
brain by infected monocytes.
-
Even though neurons do not appear
to be directly infected, there is substantial neuronal loss, most likely
due to viral products and soluble macrophage/microglial factors.
-
Putative soluble factors leading
to neuronal death include: IL-1, IL-6 and TNF.
-
Nitric oxide production in neuronal
cells is observed when exposed to gp41 viral glycoprotein.
-
HIV gp120 glycoprotein may interfere
with intracellular calcium regulation in neurons. High intracellular levels
of calcium lead to major dysfunction in vital enzymes systems.
Continue
Back |
|
|