Coagulation Disorders Tutorial
 
Introduction

Very Sociable Guy

Chest Pain

Girl with a Rash  

England 1944

Trouble Healing

Morning Stiffness

Bruises Easily

Shortness of Breath

Drug Interactions

Review

Thanks to

Quiz Please

 Heck yes this is von Willebrand disease.
  • VW is the most common inherited bleeding disorder.
  • It has a frequency of 1% of the population, although some go undiagnosed.
  • There are over 20 variants of VW, which can be grouped as follows:
Major Types of von Willebrand Disease
 
Type Incidence              Description
  I   70-80% Quantitave defect with low levels of vWF
  IIa    10-15% Qualitative defect, normal levels of vWF, but they don't combine to form high molecular weight multimers
  IIb    Rare Qualitative defect with loss of highest molecular weight multimers; thrombocytopenia
  III   Very rare Total absence of vWF. Autosomal recessive
Plt-type    Rare "Pseudo-von Willebrand disease" Defect in GP-Ib; thrombocytopenia with large platelets
Acquired   Associated with autoimmune diseases and malignancies.
  • Here are the common tests we use to diagnose von Willebrand disease.

So what are we going to do for Mrs. JK?                                                         Back 

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