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Symptoms & History
Physical Findings
Stop & Think
Lab and X-Ray
Differential Diagnosis
The Disease
Treatment
Conclusions
Quiz & Evaluation
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Endocrinopathies are the most common paraneoplastic syndrome.
Cushing's syndrome
- Paraneoplastic Cushing's
syndrome is one of the more common.
- Approximately 50%
with paraneoplastic Cushing's have it as a result of a small cell cancer
of the lung. Less commonly, pancreatic carcinomas and neural tumors.
- We see an elevation in
both tumor derived ACTH and propriomelanocortin (POMC).
- POMC is not elevated
in true pituitary Cushing's Disease.
Hypercalcemia
- Probably the
most common paraneoplastic endocrinopathy.
- By definition, it is
not due to skeletal metastasis.
- Parathyroid Hormone
Related Protein (PTHrP) from squamous cell carcinoma of lung, breast
cancer, renal cell carcinoma, ovarian carcinoma and even some lymphomas.
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