General and Systemic Histopathology, C601&C602
    Slide 59: Colon with acute ulcerative colitis
    This can be a challenging slide. There are only islands of remaining mucosa, separated by large expanses of ulceration.  Look in the base of the ulcers and just to the edge of the residual mucosa for the best examples of granulation tissue. 

    See this slide with the virtual microscope.

    The picture is from the edge of an ulcer, and shows focal absence of the mucosa. There is a mixed acute and chronic inflammatory infiltrate in the base of the ulcer with lots of granulation tissue. You will see many angioblasts and reactive fibroblasts in these areas of healing. Crypt abscesses are seen in the base of the crypts. This feature may not be very apparent as this case is relatively advanced and these earlier changes are simply overwhelmed by the degree of inflammation. 

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