General
and Systemic Histopathology, C601&C602
Slide 95: Kidney with diabetic nephropathy
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Not much to see grossly
here. Most of the changes in this slide are to be found in the cortex.
See this slide with the
virtual microscope. |
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The glomerular changes
present in this slide are one of the hallmarks of this disease. Note the
irregular thickening of the basement membrane of the glomeruli and the
hyalinized and thickened walls of both the afferent and efferent arterioles.
You will also see some coexisting larger vascular disease and chronic pyelonephritis.
Chronic infections and tissue hypoxia go hand in hand in this disease.
The chronic pyelonephritis is a part of this picture, but does occur by
itself. Know the difference between chronic pyelonephritis and diabetic
renal disease. |
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