General and Systemic Histopathology, C601&C602
    Slide 160: Malignant Lymphoma of Salivary Gland
    There is a tiny bit of normal salivary gland on this slide.  As you will see, the majority of the gland has been replaced by the lymphoma.

    See this slide with the virtual microscope.

    Look at the edges of the fragments of tissue and you should be able to spot some salivary gland in one of the fragments. You will see everywhere else, a sea of lymphocytes with a "diffuse" infiltrative pattern replacing the entire gland. These are medium sized lymphocytes and many show nuclear "cleaves or grooves." In addition to malignant lymphomas, there are several conditions in which one sees a profound lymphocytic infiltrate of the salivary gland. Can you think of any? Maybe associated with ocular manifestations? 

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