General and Systemic Histopathology, C601&C602
    Slide 176: Lymph Node with Metastatic Seminoma

    You just have to believe us that this was a lymph node at one time. It's all but totally replaced with metastatic seminoma.

    See this slide with the virtual microscope.

    The seminoma cells may not be as easy to see as you think. Some will be very large and have vesicular nuclei and others may seem to disappear right into the lymphocytic background. The node is largely replaced so practically everywhere you look you should see tumor. Some of the smaller cells may resemble lymphocytes, a feature that sometimes makes it hard to diagnose if only a very small portion of the node is replaced. You have other such tumors in your set to compare this one with.

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