General and Systemic Histopathology, C601&C602
    Slide 30: Solitary Plasmacytoma

    I am not too sure you will be able to tell the tissue of origin here, but it is spleen. These tumors can occur in many different organs, liver, spleen and bone marrow being most frequent. The plasma cells in this lesion may be active, and if so produce a monoclonal gamma globulin or portion of gamma globulin. (Be sure you understand what is meant by an electrophoretic spike.)  On occasion no spike is seen in the serum and the reason is that the protein being elaborated is  so small that it is cleared in the urine.  Checking the urine for a gamma globulin spike is always a good idea in plasma cell tumor. 

    See this slide with the virtual microscope.

    The story here is simply plasma cells.  Essentially every cell in the field is a plasma cell.  As I try to emphasize above, it's the protein they are making that needs to be watched and understood.

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