General and Systemic Histopathology, C601&C602
    Slide 57: Hodgkin's Disease in Spleen

    The areas of splenic involvement are pretty obvious here, but this isn't always the case.  Look at the uninvolved spleen first to get oriented and then focus on the areas of tumor.

    See this slide with the virtual microscope.

    The involvement with Hodgkin's is easy to see in this slide, although this is not always the case. You should be able to find Reed-Sternberg cells within this splenic implant. Remember that when trying to identify them, it is essential that they are in "their proper background." That is to say that they are seen with the Hodgkin infiltrate consisting of lymphocytes, plasma cells and especially eosinophils. There are many cells seen in a reactive lymph node that will mimic the Reed-Sternberg cell. Before identifying anything as one of these diagnostic cells, be sure it is in its proper setting! 

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