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General and Systemic Histopathology, C601&C602
     
    Slide 64: Lung with squamous metaplasia of bronchial mucosa
    The process of metaplasia is found intermixed with the typical ciliated columnar epithelium. This is a reactive or adaptive process and  not a true malignancy.  What is the definition of metaplasia?

    See this slide with the virtual microscope.

    This picture is of bronchial mucosa, showing the reactive replacement of one type of epithelium for another. It is technically not a neoplastic process, although continued injury of the sort that lead to the metaplasia, can lead to dysplasia and possibly cancer. Here we see respiratory epithelium being replaced by squamous. Smoking was the injury that lead to this alteration. Observe the inflammatory reaction beneath the mucosa. 


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