|Note how "meaty" the
bone marrow space is. Much of the hematopoietic space has been replaced
by scar tissue and tumor.
See this slide with the virtual microscope.
|This slide shows metastatic "transitional cell carcinoma" in the bone marrow. What are the sources of "transitional cell carcinoma?" First, try to get oriented by finding some bone spicules and hematopoietic tissue. The malignant cells occur in clusters and closely resemble malignant squamous cells. Although these cells don't look too wild, they are not in the right place. Observe the "desmoplasia" (i.e. fibrosis) associated with the groups of tumor cells.|