In this laboratory, we are looking at the principal differences between cells that exhibit normal cell growth and those that have unregulated or altered growth. It's not the purpose to study the individual malignancies, rather the process and general histological appearance. The term "neoplasia" does not necessarily imply malignancy. It simply means "new growth," and it applies to both benign and malignant processes. When finished with this laboratory, you should know what it is meant by the terms: metaplasia, dysplasia and malignancy. When dealing with the cytological aspects of malignant cells, we talk about the nuclear/cytoplasmic ratio as well as various degrees of nuclear hyperchromasia and angulation of the nuclear margins, nuclear molding as well as the mitotic count. These are more terms you will need to be familiar with. On the histological level, you will encounter terms such as: gland within gland. Be sure you can define terms such as carcinoma, sarcoma and adenocarcinoma. You will learn more specific terms as they apply to the individual systems as we work our way through the course.
 

Slide 21, familial polyposis of the colon.	Slide 21, familial polyposis of colon.	Slide 32, adenocarcinoma of the rectum.	Slide 23, metastatic transition cell carcinoma in bone marrow.
Slide 64, lung with squamous metaplasia of bronchial mucosa.	Slide 101, squamous cell carcinoma of the lung.	Slide 101, squamous cell carcinoma of lung.	Slide 116, skin with malignant melanoma.
Slide 116, malignant melanoma of skin.	Slide 143, small intestine with carcinoid	Slide 149, pituitary adenoma.	Slide 157, skin with recurrent squamous cell carcinoma.
			I'd like to take the quiz now.
Slide 159, teratoma of ovary.	Slide 223, Cervical PAP smear with dysplasia	Normal Colon

Mark Braun, MD braunm@indiana.edu
Copyright 1998, the Trustees of Indiana University