Coagulation Disorders Tutorial
 
Introduction

Very Sociable Guy

Chest Pain

Girl with a Rash  

England 1944

Trouble Healing

Morning Stiffness

Bruises Easily

Shortness of Breath

Drug Interactions

Review

Thanks to

Quiz Please

Let's check for factor V Leiden first.
 
  • This is by far the most common protein abnormality leading to thrombosis.
    • It occurs in approximately 5% of the Caucasian population.
    • The DNA sequence for both wild-type and Leiden factor is known.
  • DNA probe of Mr. CV's genome reveals he has the Leiden variant of factor V.
Once activated, V Leiden cannot be degraded by protein C. It's a runaway train.
 
         Condition Incr. risk
Heterozygosity     7X
Heterozygosity + birth control pills    35X
Homozygosity    80X
   
 

 
Five percent of the population, is this for real?                                                   Back

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