Very Sociable Guy

Chest Pain

Girl with a Rash  

England 1944

Trouble Healing

Morning Stiffness

Bruises Easily

Shortness of Breath

Drug Interactions

Review

Thanks to

Quiz Please

The question to resolve is this: Is the thrombotic condition the result of

An overactive clotting system, or Underactive thrombolytic system?

• Antithrombin III assay: Antithrobin III (also known as heparin co-factor), is the principal agent that degrades activated Factors II and X. Obviously, ATIII is an important braking force on the clotting system.
• Protein C and protein S assays: These are vitamin K dependent proteins that are involved in degradation of activated Factors V and VIII. Another important brake.
• Here we can measure both quantity and function.
• DNA-based assay for Factor V Leiden: The Leiden factor is an abnormal Factor V, that once activated cannot be degraded. In other words, you're off to the races.
• There are at least 5 subtypes known.
• The one seen in Caucasians occurs in about 5% of the population.

Several more important tests for thrombosis.                                                 Back