Pathology Case Studies

Mr. PF made an antibody against part of the streptococcus. Antigen-antibody complexes became trapped in the glomerulus. Not because of their size, but because of their charge. The complexes cleared the basement membrane, but became trapped under the foot processes of the epithelial cells. In the EM to the right, we see them as dense, lumpy deposits on the outside of the basement membrane. In the lab we can measure this process by monitoring the titer of anti-strep antibodies.
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