| Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
Please |
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Acute
lymphocblastic leukemia / lymphoma (ALL)
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Approximately 2,500 new cases
each year in the US.
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Most are under 15 years
of age, with peak for ALL of 4 years.
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Does occur in adults but very
infrequently.
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Whites more common.
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Pre-B cell acute lymphoblastic
leukemia.
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Pre-B cells express terminal
deoxytransferase (TdT) activity.
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Lack surface IgG
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Positive for CD19; +/-
for CD10 and CD20
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Many chromosomal translocations
invloving the Ig locus; t(12;21), t(9;22)
the Philadelphia chromosome and t(4;11).
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Children predominate,
with symptoms of cytopenias, due to extensive bone marrow
involvement.
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Pre-T cell acute lymphoblastic
lymphoma
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Pre-T cells express TdT
enzyme activity and CD1 antigen.
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Variable expression of other
T-cell markers, CD2, CD3, CD4....
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Multiple chromosomal translocations,
most invlove T-cell receptor loci.
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Adolescent males predominate.
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Mediastinal and thymic
involvement.
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Variable spleen, liver and marrow
involvement.
Lymphoblastic leukemia
specifics.
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