| Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
Please |
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Chronic
myeloproliferative disorders
-
The multipotential stem cell
is the neoplastic cell in these conditions.
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The neoplastic stem cell
does the following:
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Clones itself, as all stem cells
do.
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Gives rise to one or more
of the following:
-
a malignant erythroid
line.
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a malignant myeloid line
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a malignant megakaryocytic
line.
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In time, these deranged cell
lines replace the bone marrow, effectively squeezing out
and suppressing the healthy population.
-
Chronic myeloproliferative disorders
differ
from other leukemias in that initially the malignant
cell
lines do complete differentiation to their respective "terminal" cell.
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RBC
-
WBC and/or
-
Platelet forming megakaryocytes.
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This unregulated proliferation
of the neoplastic derived lines results in
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Marrow hypercellularity
with increased hematopoiesis, and
-
Elevated peripheral blood
counts.
There are four major
categories of MPDs.
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