| Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
Please |
|
Types
of myeloproliferative disorders.
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Chronic myelogenous leukemia
(CML)
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Polycythemia vera (PCV)
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Essential thrombocythemia, and
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Myelofibrosis with myeloid metaplasia.
We're going focus on CML, but
here are some interesting things common to all four MPDs:
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The neoplastic stem cells
are able to circulate in the blood.
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This means they can colonize
other potential hematopoietic organs.
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Spleen most frequently,
causing marked splenomegaly.
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Less often liver and lymph nodes.
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Often terminate as marrow
fibrosis
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Leads to profound peripheral
cytopenias.
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Progress in time to an acute
leukemia (blast crisis), CML especially.
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There is considerable overlap
in clinical presentations.
Chronic
myelogenous leukemia.
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