Measuring WBCs

• The Basics
• Reactive
• Terms

• Acute Leukemia
• Dysplasia
• Myeloproliferative

• Acute
• Chronic  

Quiz Please

• CML is a clonal stem cell malignancy.
• Primarily adults, ages 25-60. Peak 30-40.
• Distinctive genetic abnormality, t(9;22)(q34;q11).
• Translocation involves BCR gene and The ABL gene.
• The resulting fusion BCR-ABL gene produces a novel protein with tyrosine kinase activity.
• This novel gene product causes run away proliferation in the affected stem cell.
• The residual chromosomal fragment of chromosome 22 is known as the Philadelphia Chromosome (Ph')
• Click here to see this translocation .
• The malignant stem cell carrying the t(9;22) translocation reproduces its own kind and 
• Rapidly generates "diseased" granulocytic precursors, leading numerous functionless PMNs.
• In time, the healthy bone marrow constituents are replaced by the progeny of this sick stem cell.