Measuring WBCs

• The Basics
• Reactive
• Terms

• Acute Leukemia
• Dysplasia
• Myeloproliferative

• Acute
• Chronic  

Quiz Please

Here's a B-cell neoplasm with a name that makes sense. See the whiskers on the surface?

• Cells are positive for tartrate resistant acid phosphatase (TRAP).
• Cells are positive for typical B-cell markers, CD19 and CD20.
• Oddly, these cells are capable of phagocytosis.
• Often massive splenomegaly necessitating splenectomy.
• The old term for this is "leukemic reticuloendothelialosis" because the bone marrow replacement with malignant cells that superfically look like endothelial cells, fibroblasts. 
• Indolent course with many people living for years with the disease.
• Standard B-cell anti-tumor regimens are not effective.
• Most patients respond to alpha interferon and newer drugs.
• Granulocyte colony-stimulating factor is helpful with leukopenia.

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