| Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
Please |
|
A
little more on the pathogenesis of acute myelogenous leukemias.
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One cell in the line of maturation
becomes malignant.
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A variety of chromosomal abnormalities
are known, here's an example of one seen with acute promyelocytic leukemia
(M3 leukemia)
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t(15;17) translocation is common
in promyelocytic leukemias.
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Once a malignant cell has developed,
there is no further maturation of that malignant cell; its only desire
is to reproduce its own kind.
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In time, the clonal proliferation
of this one malignant cell replaces the bone marrow, leading to the symptoms
and eventually death.
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Oddly, the replication rate
of the malignant cells is lower than the healthy cells, the problem is
they never mature. They just accumulate in the marrow and in time replace
it. They even are able to cause some form of suppression of the healthy
elements.
Different
forms of AML
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