| Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
Please |
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Myelodysplastic
syndromes (MDS)
Just like many other tissues
of the body, there can be dysplasia of the bone marrow. You know,
dysplastic
maturation of the cervical epithelium, bronchial mucosa,
etc. You can have abnormal maturation of the bone marrow that
may lead
to overt malignancy.
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Myelodysplastic syndromes are
a heterogeneous group of clonal stem cell disorders.
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Because the problem is
with the multipotential stem cell, all cell lines (erythroid,
granulocytic and megakaryocytic) coming from the diseased stem cell
are sick too.
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The maturation defect
of the multipotential stem cell leads to
-
ineffective hematopoiesis,
plus
-
confers an increased risk
advancing to overt AML
-
The bone marrow of patients
with MDS is partly or wholly replaced by the clonal proliferation from
the mutant stem cell. This leads to a paradoxical histology:
-
hyperplastic bone marrow
(it's
really not doing its job)
-
peripheral blood shows pancytopenia
(ineffective maturation)
The basic pattern
of MDS.
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