| Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
Please |
|
Myelodysplastic
syndromes develop in two settings:
-
Idiopathic or primary MDS
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Unknown etiology
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develops insidiously
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typical patient is over 50
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Therapy related MDS (t-MDS)
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Complication of chemotherapy
(especially alkylating agents) and/or radiation therapy.
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Usually within 8 years of exposure.
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Highest rate of progressing
to AML
Morphologic changes of bone marrow in MDS
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Disordered (dysplastic) maturation
of all three cell lines in bone marrow (erythroid, myeloid and megakaryocytic).
-
Dysplasia of erythroid line
is most easily seen.
What about changes
in the peripheral blood?
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