| Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
Please |
|
Summary
of myeloid neoplasms.
In the case of a myeloid
leukemia, it matters where the malignant cell develops.
-
In a committed
line (typical of acute leukemias)
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Or at the level of the stem
cell (the situation with chronic myelogenous leukemia.)
Here are the basic divisions
of myeloid derived neoplasms:
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Acute myelogenous leukemia,
characterized by clonal proliferation of an immature myeloid precursor
cell, arising somewhere down the maturational sequence of a committed cell
line. (FAB classification)
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Myelodysplastic syndromes,
characterized by ineffective erythropoiesis and a variety of cytopenias.
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Chronic myeloproliferative
disorders, of which chronic myelogenous leukemia is one. These are
stem
cell disorders.
-
Chronic myeloproliferative disorders
are characterized by increased production of "terminally" differentiated
myeloid cells (RBCs, WBCs, platelets, etc.).
-
When the stem cell is sick,
everything flowing from it is sick too.
Take a
break.
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