Introduction
Measuring
WBCs
Myeloid
Leukemias
Lymphoid
Leukemias
Sources
of Error
Quiz
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The
last of the MPDs is myelofibrosis with myeloid metaplasia.
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You got it, another stem
cell neoplasm.
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In this case, marrow fibrosis
is the key feature.
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Bone marrow findings
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"Dry tap," in other words
you can't aspirate anything while attempting a marrow aspirate.
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The fibrosis is thought
be due to release of fibrogenic factors from megakaryocytes and/or platelets.
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Platelet derived growth factor
(PDGF)
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TGF-beta
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Peripheral blood.
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Marked cytopenias.
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Nucleated RBCs and RBC
precursors.
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Extensive extramedullary
hematopoiesis.
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Spleen, liver, lymph nodes.
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Survival varies from 1 to 5
years.
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Infections
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Bleeding
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Rarely transformation to AML
(blast crisis).
Summing
up myeloid neoplasms.
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