Introduction
  Evaluation
  Short of breath
  Too tired
  The dwindles
  Weight loss
  Healing
  Chemotherapy
  Mom to be
  Very sociable
 
   Thanks To
   Quiz
 
 
 
 Mark W. Braun, MD
 braunm@indiana.edu

 
   Nutrition and Diagnosis-Related Care

 

 
 

Her kidneys are in real trouble. The non-enzymatic glycosylation of the proteins of the arterioles has led to interstitial tissue scaring and marked injury to the glomeruli.
  • Her creatinine clearance indicates she has practically no kidney function left.
  • With diabetes, all parts of the kidney are damaged:
  • Large vessels with advanced atherosclerosis and small vessels with thickening of the theirs walls.
  • Interstitial hypoxia leads to infections and scaring.
  • Glomerular basement membrane damage leads to poor filtration, with retention of waste products and loss of proteins.
  • Roll the cursor over the image.
   Diabetic glomerular changes

Would a normal glomerulus help?

As the renal parenchyma goes, ancillary jobs are not done, such as
  • The production of erythropoietin (her anemia is the result of this), and
  • Electrolyte management: Na+ and K+ and phosphates.
  • Don't forget, H+, it's an electrolyte too. Renal failure leads to acidosis.

The total management is beyond the scope of what we're doing, but here are the basics.

 
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