Coagulation Disorders Tutorial
 
Introduction

Very Sociable Guy

Chest Pain

Girl with a Rash  

England 1944

Trouble Healing

Morning Stiffness

Bruises Easily

Shortness of Breath

Drug Interactions

Review

Thanks to

Quiz Please

Is there something that affects clotting with a normal PT and aPTT?
 
  • Protein C deficiency
  • Protein S deficiency
  • Anti-thrombin III
 
  • Elevated homocysteine
    • Mr. JH's value is 28 micromol/L
    • Desirable value = <13 micromol/L
Inborn errors of homocysteine metabolism  

 

 

            Enzyme

Cofactor
   
Cystathionine synthetase Vitamin B6
Methionine synthetase

Vitamin B12

Methylenetetrahydrofolate reductase

   Folate

  • Elevated levels also seen with low dietary intake of folate, vitamins B6 and B12.

 

 Are you kidding? An MI on the basis of high homocysteine?                            Back

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