Coagulation Disorders Tutorial
 
Introduction

Very Sociable Guy

Chest Pain

Girl with a Rash  

England 1944

Trouble Healing

Morning Stiffness

Bruises Easily

Shortness of Breath

Drug Interactions

Review

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Quiz Please

Intelligent use of the lab will solve the mystery.
 
Rather than ordering levels on all the factors, we can now narrow it down to just four: XII, XI, IX and VIII.

Factor XII and XI deficiencies are pretty uncommon, so let's start with the most frequent.

  • Statistically, von Willebrand's disease is actually the most common genetic bleeding disorder, but his aPTT is longer than usually seen with this, and his type of bleeding suggests something not linked to platelet response.

Let's start with by checking levels in the proteins unique to the intrinsic system.

  • Of these, factor VIII deficiency is most common, followed by IX. Just playing the odds, we get a level on VIII.
    • His factor VIII is 100% of expected.
  • Well, these things happen. So we go to the next most common, factor IX.
    • His factor IX is 12% of expected.

 

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