Coagulation Disorders Tutorial
 
Introduction

Very Sociable Guy

Chest Pain

Girl with a Rash  

England 1944

Trouble Healing

Morning Stiffness

Bruises Easily

Shortness of Breath

Drug Interactions

Review

Thanks to

Quiz Please

Congenital and otherwise interesting states of hypercoagulation.
 
  • Screwy proteins
    • Leiden factor V (multiple variants, 5% of people).
    • Abnormal Prothrombin
    • Once turned on, these two can't be shut off.
  • Hyperhomocysteinemia (MI at young age; folate)
    • Endothelial injury
  • Antiphospholipid syndrome
  • (APS)
    • Prolonged aPTT, but really hypercoagulable.
  • Protein C & S deficiency (remember Coumadin)
  • Antithrombin III deficiency.
  • High levels of clotting factors
    • Cancer
    • Estrogens and birth control pills
  • Be extra careful if you're asked to be a belly gunner in a B17 (stasis and immobilization).
  • Even more stuff just in case you were getting complacent.

 

OK, so what about bleeding tendencies?                                                         Back

 

Main Index | Slide Table of Contents | Case Studies Table of Contents