Coagulation Disorders Tutorial
 
Introduction

Very Sociable Guy

Chest Pain

Girl with a Rash  

England 1944

Trouble Healing

Morning Stiffness

Bruises Easily

Shortness of Breath

Drug Interactions

Review

Thanks to

Quiz Please

 Since the PT and aPTT overlap, you can exclude some proteins depending on which is prolonged.
  • If the PT is prolonged, but the aPTT is normal, there's only one possibility. Factor VII.
  • A prolonged aPTT with normal PT is a little more complex.
  • To the right is an algorithm that provides the basics.
  • First off, you know the defect is not in the final common path and it can't be factor VII.
  • So it has to be a protein(s) unique to the aPTT.

What if both aPTT and PT are long?

  • Multiple defects, or
  • Final common path defect.
  • Once narrowed down, get specific coagulation factor levels.
  
What about someone with a compelling history, but normal studies?                           Back

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