• Thrombocytopenia
• Moderate to high anti-cardiolipin antibodies
• Either IgG or IgM,
• On two occasions 12 weeks apart.
• Other serology:
• ANA may be present in low titers.
• Anti-ss DNA frequently seen.
• Coombs +/-, maybe hemolytic anemia.

• Antiphospholipid antibodies
• IgG, IgM or even IgA.
• Directed against proteins of the clotting system that bind to the phospholipids.
• Prothrombin.
• Beta2-Glycoprotein-1 (B2-GP1).

OK, so we have a state of hypercoagulability masquerading as a prolonged aPTT.

What to do we do to help Mrs. JN?                                                             Back