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Introduction
Measuring WBCs
Myeloid Leukemias
Lymphoid Leukemias
Sources
of Error
Quiz Please
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Chronic lymphocytic leukemia (CLL).
- Chronic lymphocytic
leukemia and small lymphocytic lymphoma are morphologically and
phenotypically indistinguishable.
- These two conditions
differ only with respect to the degree of peripheral blood lymphocytosis
.
- Tell me ->
- For the diagnosis of
CLL it takes an absolute peripheral lymphocyte
count of >4,000.
- Chronic lymphocytic
leukemia is seen mostly in older adults and is the most common
leukemia in the US.
- The lymphoma side of
this coin, small lymphocytic lymphoma, is not very common and represents
only about 4% of all non-Hodgkin lymphomas.
- Neither condition is
very common in Asian countries.
- The tumor cells are small
mature appearing lymphocytes.
- Express B-cell markers;
CD19 and CD20
- Plus on T-cell marker,
CD5.
- Malignant cells often
have IgM on their surface.
- Some patients even have
a small gamma "spike."
- Cells are fragile. They
rupture when making the blood smear, producing a purple blob called a "smudge
cell."
-
Splenic white pulp and liver portal tracts
are sometimes involved.
Show me
them cells
.
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