Measuring WBCs

• The Basics
• Reactive
• Terms

• Acute Leukemia
• Dysplasia
• Myeloproliferative

• Acute
• Chronic 

Quiz Please

It's hard to imagine, but the same lymphocytic malignancy in two different patients can have two very different morphologies. 

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• Lymphocytic leukemia is a malignancy of lymphocytes with widespread involvement of the bone marrow and the presence of malignant cells in the peripheral blood.
• Lymphoma applies to lymphocytic neoplasms arising in discrete tissues, such as lymph nodes, spleen and even bone marrow. Although it can happen, it is unusual to have a significant leukemic phase.
• Both leukemias and lymphomas can be grouped by cell lineage.
• T derived cells
• B derived cells
• Lymphoid leukemias are grouped by degree of cell differentiation and expected clinical outcome.
• Acute (lymphoblastic, rapid course if untreated)
• Chronic (mature cells, indolent course)
• Immunophenotyping plays an important role in classification and predicting outcomes.