The Pre-B cell lymphoblastic leukemia always has substantial bone marrow involvement.
- Believe it or not, this picture is of a bone marrow from an ALL patient.
- In this frame there is nothing but lymphoblasts.
- It's easy to see how the principal symptoms are due to the secondary cytopenias (anemia, infections and bleeding).
- This is also why some children will complain of leg or knee pain, which is actually bone pain because of the marrow space expansion.