Mental Status Changes
 
Introduction
Acute Confusion
   Infectious
   Metabolic
Cases
   Headache
   Fever & Confusion
   Focal Weakness
   Nice Doggie
   She's Talking a Lot
   Hemiparesis
   Unconscious
   Police Call
 

Chloramphenicol is an excellent drug for meningitis.

  • Used little in the US because of fear of aplastic anemia.
  • Wide spectrum, covering most gram negative and gram positive bugs that routinely cause meningitis.
  • Also very useful for anaerobic infections.
  • To the right is a an autopsy photo of a case of Streptococcus pneumoniae meningitis.
  • Care should be taken to be sure Adhiambo does not have a pneumonia as well.
  • Treatment is for 14 days

Photo courtesy of: ImmunizationEd.org

An ELIZA for HIV was sent because of Adhiambo's thrush. It was positive.

  • Her immunosupression does not relate directly to a risk of meningitis.
  • Community acquired meningitis, of many causes, is endemic in Kenya.

Adhiambo's differential diagnosis should include

  • Chronic meningitis, such as TB and cryptococcus.
  • Meningococcus and other bacteria
  • Cerebral malaria

The next patient is a 17 year-old with right-sided weakness and confusion.

 
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