General and Systemic Histopathology, C601&C602
The clinical manifestations of gastrointestinal diseases are not always as straight forward as one might think. Although abdominal pain and diarrhea are generally pretty good indications of bowel disorders, lethargy and easy fatigability may not immediately come to mind. In this unit we will look at a number of conditions that may have some rather peculiar and unexpected presentations. Use the following examples as a starting point to refine and expand your knowledge. In the past it has been very helpful for students to review their observations in small groups and quiz one another on the histology and clinical presentations of these conditions. Here are a few things to concentrate on.
Among the common and
important conditions we will study are ulcer disease, infectious enteritides,
neoplastic disease, vascular disorders and even primary endocrine abnormalities
of the bowel. Important categories of pathology are the diseases grouped
under the heading of "inflammatory bowel disease." Here are two curious abnormalities
that can be quite devastating and even fatal, ulcerative colitis and Crohn's
disease. Even today the etiology for both is not fully understood. Clearly
there will be others, but what is listed above you will need to know in
detail. Good luck.